@article{zak_results_2014, title = {Results 2 {Years} {After} {Matrix}-{Associated} {Autologous} {Chondrocyte} {Transplantation} {Using} the {Novocart} {3D} {Scaffold}: {An} {Analysis} of {Clinical} and {Radiological} {Data}}, issn = {1552-3365}, shorttitle = {Results 2 {Years} {After} {Matrix}-{Associated} {Autologous} {Chondrocyte} {Transplantation} {Using} the {Novocart} {3D} {Scaffold}}, doi = {10/f6ffg3}, abstract = {BACKGROUND:A range of scaffolds is available from various manufacturers for cartilage repair through matrix-associated autologous chondrocyte transplantation (MACT), with good medium- to long-term results. PURPOSE:To evaluate clinical and magnetic resonance imaging (MRI) outcomes 2 years after MACT on the knee joint using the Novocart 3D scaffold based on a bilayered collagen type I sponge. STUDY DESIGN:Case series; Level of evidence, 4. METHODS:Of 28 initial patients, 23 were clinically and radiologically evaluated 24 months after transplantation. Indications for MACT were chondral or osteochondral lesions on the knee joint with a defect size {\textgreater}2 cm(2), no instability, and no malalignment (axis deviation {\textless}5°). Then, MRI was performed on a 3-T scanner to assess the magnetic resonance observation of cartilage repair tissue (MOCART) and 3-dimensional (3D) MOCART scores. A variety of subjective scores (International Knee Documentation Committee [IKDC], Knee injury and Osteoarthritis Outcome Score [KOOS], Noyes sports activity rating scale, Tegner activity scale, and visual analog scale [VAS] for pain) were used for clinical evaluation. RESULTS:Two years after MACT, the MRI evaluation showed a mean MOCART score of 73.2 ± 12.4 and a 3D MOCART score of 73.4 ± 9.7. Clinical results showed mean values of 69.8 ± 15.2 for the IKDC; 51.6 ± 21.2, 86.5 ± 13.9, 54.5 ± 23.6, 65.0 ± 8.0, and 91.5 ± 10.6 for the KOOS subscales (Quality of Life, Pain, Sports and Recreation, Symptoms, and Activities of Daily Living, respectively); 77.5 ± 12.7 for the Noyes scale; 4.4 ± 1.6 for the Tegner activity scale; and 1.8 ± 1.7 for the VAS, with statistically significant improvement in all scores other than KOOS-Symptoms. CONCLUSION:Undergoing MACT using the Novocart 3D scaffold is an applicable method to treat large focal chondral and osteochondral defects, with good short-term clinical and radiological results.}, language = {ENG}, journal = {The American Journal of Sports Medicine}, author = {Zak, Lukas and Albrecht, Christian and Wondrasch, Barbara and Widhalm, Harald and Vekszler, György and Trattnig, Siegfried and Marlovits, Stefan and Aldrian, Silke}, month = may, year = {2014}, pmid = {24817007}, keywords = {Department Gesundheit und Soziales, Institut für Gesundheitswissenschaften, Publikationstyp Schriftpublikation, SP IGW Clinical \& Healthcare Research, Studiengang Physiotherapie, peer-reviewed}, }